"We, who are working in a system that is incapable of caring for its patients in a timely fashion due to general incapability of the NHS to appropriately care for its population without doctors striking on a daily basis, and are thus under significant pressure to get patients done as quickly as possible, have evaluated that 26Gy in 5 fractions once daily over a week is non-inferior in terms of local recurrence, which the trial we ran was powered for.
The trial, which was not powered to detect toxicity differences, showed no statistically significant differences in grouped toxicities. In multiple individual toxicities that may be of interest to individual patients on an individualized basis, there is a statistically significant worsening of late toxicity metrics that we measured between 26Gy in 5 fractions and 40Gy in 15 fractions. While this may be of interest to individual patients, we have buried these data deep within the supplement and announced that all toxicities are 'equal' between 26Gy in 5 fractions and 40Gy in 15 fractions, as we work in a system that is currently crumbling in terms of financial pressures, and we are motivated to get patients done as quickly as possible. We decide to buck the trend of personalized medicine, including shared decision making, that is being presented on a global scale and instead proceed with cookie cutter assembly line medicine for our early stage breast cancer patients."
If I have a prostate cancer patient who wants conventional fx even for prostate alone and it gets denied, I would p2p and then appeal, including complaint to insurance commissioner. And that's to give a patient the autonomy to pick the treatment with the lowest global toxicity rate, driven by a decrease in acute GI toxicity by picking conventional. Same thing with prostate SBRT ever becoming something beyond 'A' standard of care.
Similarly, if I have an early stage breast cancer patient who wants 40/15 for mod hypo for tangents alone and it gets denied in favor of 5fx, I would do similarly. And that difference is for LATE toxicity.