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The combo of MRI fusion biopsy and PSMA PET has led to major risk group migration without us really knowing how dangerous a lot of this disease is.Anecdotally, I'm seeing a lot more GG4-5, N+ prostate cancer than I did in training. I've seen some mention on the MedNet that others have anecdotally been seeing more node+ and retroperitoneal spread from prostate cancer.
Makes you wonder how much the patterns really are changing as we see less GG1 prostates just getting observed.
Pretty typical consult today. 74 y/o on AS for GG1 disease diagnosed by TRUS bx 2 years ago. No concerning PSA kinetics. Repeat MRI fusion bx shows GG4 disease now.