Would it be in my interest to do a 7 on 7 off gig, make 450k and then moonlight anesthesia during my off days as opposed to doing GA and then moonlighting ICU? I do prefer to do more general anesthesia but which would bring in more money?
Neither of those are great ideas. For a 26 week, 7on/off job, you have no real time off, as your work weeks are 84 hours. You're not going to want to go from one very long week to the OR, then right back to another really long week. MAYBE if you limited your OR time to one to two days during your off weeks, you could do it. The other way, of doing full-time anesthesiology and doing CCM during your vacation weeks, and some weekends off, is also not a great idea, as you'll be working a ton, with little time off, and likely not able to spend enough time in the ICU (unless you join a group that can take 20+ weeks off, and you do 8-10 in the unit) to keep sharp.
If you want to do both, either find those rare combined jobs, or do separate jobs. In the current locums market, you could actually make the most money doing locums for each, committing to a few weeks of anesthesiology here, a few ICU weeks there, and have off when you want.
Or, see if you can find a part-time critical care job (like, one week per month), and combine it with a part-time day-doc anesthesiology job (maybe 26 weeks at 40hrs/week). This may be as difficult as finding a combined position, however.
