S-100 not just a neural crest marker

[ChessMaster3000]

Langerhans cells stain S-100 positive, which I thought implies a neural crest lineage, but are clearly derived from the monocyte system, which is mesodermal. In FA it says cells express S-100 (mesodermal origin), which seems to imply that BECAUSE it expresses s-100 it IS of mesodermal origin. Given that so many neural crest derived tumors stain s-100, I find this hard to believe.

I don't know why I learned s-100=neural crest, but for testing purposes, this shouldn't be a generalization I make?

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[notbobtrustme]

nope, just gotta straight up memorize it. On average it will refer to neural crest, but like you said, there are exceptions.

 

[Leonidis I]

a cursory look at wikipedia shows that it is found in tons of other types of cells including ", chondrocytes, adipocytes, myoepithelial cells,macrophages, Langerhans cells, dendritic cells, and keratinocytes" as well as some breast epithelial tissue. http://en.wikipedia.org/wiki/S-100_protein

i think the reason we think that S-100 marker automatically means neural crest is because maybe it has such a high sensitivity/specificity as a marker for neural crest whereas with other cell types there are better markers available

 

[sanj238]

a cursory look at wikipedia shows that it is found in tons of other types of cells including ", chondrocytes, adipocytes, myoepithelial cells,macrophages, Langerhans cells, dendritic cells, and keratinocytes" as well as some breast epithelial tissue. http://en.wikipedia.org/wiki/S-100_protein

i think the reason we think that S-100 marker automatically means neural crest is because maybe it has such a high sensitivity/specificity as a marker for neural crest whereas with other cell types there are better markers available

many of those are mesodermal....

 

[ulikedaggers]

a cursory look at wikipedia shows that it is found in tons of other types of cells including ", chondrocytes, adipocytes, myoepithelial cells,macrophages, Langerhans cells, dendritic cells, and keratinocytes" as well as some breast epithelial tissue. http://en.wikipedia.org/wiki/S-100_protein

i think the reason we think that S-100 marker automatically means neural crest is because maybe it has such a high sensitivity/specificity as a marker for neural crest whereas with other cell types there are better markers available

Perhaps high sensitivity, but certainly not high specificity given what wiki says.

 

[ChessMaster3000]

Perhaps high sensitivity, but certainly not high specificity given what wiki says.

speaking of neural crest markers, FA lists bombesin as associated w/ neuroblastoma. I've read that bombesin can be shown in other neural crest derivatives. Has anyone seen a question where it is associated w something other than a neuroblastoma?