I hear you, and as a Rad Onc, I agree. But, the reality is different.
Stage III endometrial cancer in the US is frequently a chemo primary disease. I've pushed to at least let vaginal brachy remain in the mix but my Gyn/Oncs are NOT enthusiastic for sequential chemo then radiation the way ASTRO considers an acceptable option (which is all just based on 'expert opinion')
I personally think the best thing for these patients is full dose chemo, re-staging, then followed by whole pelvic RT but I don't have any prospective evidene to support this regimen and thus can't convince the GynOncs. Would be an easy NRG trial - CarboTaxol +/- sequential whole pelvis RT. I'm sure people have recommended it in NRG and been shut down by strong opinionated GynOncs (in the US). Similar to RTOG 0848 for pancreas but we see how long that's taking to result out....
And now with RUBY and GY018 adding open questions about adding in immunotherapy in stage III patients... it's an absolute ****show.
Can't do 9708 regimen anymore as distant mets will (almost) always be lethal while regional mets can likely be salvaged some percentage of the time.