Anybody doing BID for inflammatory breast ca outside of MDACC?

[Mandelin Rain]

If so, are you doing it routinely or selecting on basis of age, margin, nodes, chemoresponse, etc...?

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[StIGMA]

If so, are you doing it routinely or selecting on basis of age, margin, nodes, chemoresponse, etc...?

This doesn't cover every nuance but this is what we generally do:

Post-neoadjuvant chemo and mastectomy,

-If pathological partial response or no response, 51 Gy at 1.5 Gy BID followed by boost of 15 Gy BID at 1.5Gy Bid, total of 66 Gy (use 5mm bolus x 15 fractions, more if no erythema)

-If pathologic complete response, then 50 Gy at 2 Gy/fx, followed by 10 Gy boost at 2 Gy per fxn (use 5mm bolus x 15 fractions, more if no erythema)

Long-term followups can see some significant fibrosis with the BID regimen (have sent patients for HBO years after this).

 

[evilbooyaa]

Not routinely, no, we are not using BID. For similar reasons that SCLC aren't getting BID here either.

 

[medgator]

Not routinely, no, we are not using BID. For similar reasons that SCLC aren't getting BID here either.

BID is logistically difficult for many patients (and some remote practices that treat half days)

 

[elementaryschooleconomics]

BID is logistically difficult for many patients (and some remote practices that treat half days)

That's usually our barrier as well - though we do try to make the data/option clear for the patient and offer it to them.

 

[OTN]

That's usually our barrier as well - though we do try to make the data/option clear for the patient and offer it to them.

Is there good data showing improved outcomes for BID tx for inflammatory breast ca?

 

[elementaryschooleconomics]

Is there good data showing improved outcomes for BID tx for inflammatory breast ca?

Sorry - I was referencing the logistical comment from evil/medgator (and SCLC)

 

[Mandelin Rain]

Is there good data showing improved outcomes for BID tx for inflammatory breast ca?

There's good evidence, there's bad evidence, and there's MD Anderson evidence.

 

[Carotenoid]

No we don't. Logistically very difficult unless you have a hotel at your center.