MD & DO Antihistamines and Parkinson's

[Maxilla54]

Does anyone know of the mechanism(s) by which Antihistamines worsen Parkinson's disease?
(Context: Prescribing anti-emetics for PD - consultant recommends domperidone as apparently cyclizine is an antihistamine which, like prochlorperazine, may exacerbate Parkinson's disease.)

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[Radetzky]

Unclear but cyclizine is one of the safer ones.

 

[Maxilla54]

Unclear but cyclizine is one of the safer ones.

Even for anti-emesis in PD? Would you prescribe it over domperidone? My consultant (UK attending) was pretty adamant on the latter.

 

[Radetzky]

Even for anti-emesis in PD? Would you prescribe it over domperidone? My consultant (UK attending) was pretty adamant on the latter.

Domperidone is safer.