SCS for depression being studied

[lobelsteve]

The Spinal Cord Could Provide a Radical New Way to Treat Depression

With depression affecting around 1 in 10 of us at some point during our lives, the need for new and improved treatments is a top priority for researchers – and it appears that spinal cord stimulation could be one route for experts to investigate.

www.sciencealert.com

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[Orin]

The Spinal Cord Could Provide a Radical New Way to Treat Depression

With depression affecting around 1 in 10 of us at some point during our lives, the need for new and improved treatments is a top priority for researchers – and it appears that spinal cord stimulation could be one route for experts to investigate.

www.sciencealert.com

Abbott has some prior art they want to discuss with their burstdr...

 

[drusso]

The Spinal Cord Could Provide a Radical New Way to Treat Depression

With depression affecting around 1 in 10 of us at some point during our lives, the need for new and improved treatments is a top priority for researchers – and it appears that spinal cord stimulation could be one route for experts to investigate.

www.sciencealert.com

It's going to be a game-changer. The response to Stellate's for mixed anxiety/depression is compelling too.

 

[Agast]

Probably some bipolar patients switched from depression to mania or something

 

[BobBarker]

Yep, if they fail SCS psych screen we will just pop in this other SCS to treat their depression.

 

[drusso]

Yep, if they fail SCS psych screen we will just pop in this other SCS to treat their depression.

There are a lot of ways to milk a cow.

 

[murphles]

It's going to be a game-changer. The response to Stellate's for mixed anxiety/depression is compelling too.

I think it is a little early to say that it is a game changer. But all forms of neuromodulation including TMS are increasingly intriguing. Used much more in Europe for chronic pain as well.

 

[Ducttape]

this is NOT SCS.

this is TENS. not even peripheral stim.

Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern - Molecular Psychiatry

Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spinal direct current stimulation (tsDCS) in MDD. This was a...

www.nature.com

The tsDCS device 2 × 2 transcutaneous spinal direct current stimulator model 0707-A (Soterix Medical®, New York, NY) was utilized. This device is available in the US only for investigational use and was labeled accordingly.

In preparation for each tsDCS session, participants were asked to change into a gown and remain seated. Carbon rubber electrodes (4.5 × 4.5 cm) were placed inside EASYpad sponges (Soterix Medical ®) moist in saline solution (0.9% NaCl) to decrease impedance. The sponge size for the anode electrode was 5 × 10 cm and the cathode was 5 × 7 cm. The electrodes were connected to the tsDCS device through cables 188 cm in length. A detailed description of the electrode montage and tsDCS temporal characteristics are presented in Fig. 1.

screened 671 patients to get 20 suckers volunteers. 30% attrition rate out of those 20. total of 6 sham and 8 "active" patients.


all patients benefitted. the point they are making is that the treatment patients may have benefitted more. all 8 of them.

and in secondary measures, there were no real statistically significant differences in between the 2 groups.

Categorical response rate differences between the intervention groups according to MADRS score did not reach statistical significance for partial response (p = 0.08), response (p = 0.36), or remission (p = 0.34) criteria (Supplementary Table 2). A MADRS item-level analysis showed that compared to sham, active tsDCS induced a greater decrease in LS mean (±SE) MADRS “reported sadness” item (−1.8 ± 0.4 vs. −3.2 ± 0.4, p = 0.012). A statistical trend in the same direction was observed for “pessimistic thoughts” item (−0.8 ± 0.5 vs. −1.9 ± 0.4, 0.094), as well as week-8 clinical global impression-improvement (CGI-I) scale scores (2.0 ± 0.3 vs. 1.3 ± 0.3, p = 0.091). Although greater numerical decreases in the active group were observed on all MADRS items (except “reduced sleep”), no other statistically significant difference was observed between groups. There were no significant differences in change from baseline to week 8 between intervention groups on self-reported PHQ-9, MAIA, 4-DSQ, and BES scales (Table 2).

in effect, a study to justify giving a patient a TENS unit.

 

[Laryngospasm]

this is NOT SCS.

this is TENS. not even peripheral stim.

Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern - Molecular Psychiatry

Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spinal direct current stimulation (tsDCS) in MDD. This was a...

www.nature.com

screened 671 patients to get 20 suckers volunteers. 30% attrition rate out of those 20. total of 6 sham and 8 "active" patients.


all patients benefitted. the point they are making is that the treatment patients may have benefitted more. all 8 of them.

and in secondary measures, there were no real statistically significant differences in between the 2 groups.




in effect, a study to justify giving a patient a TENS unit.

Yeah yeah.. But how much can we charge? ,, can we get some KOLs in here to help us make our decisions?

 

[cowboydoc]

this is NOT SCS.

this is TENS. not even peripheral stim.

Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern - Molecular Psychiatry

Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spinal direct current stimulation (tsDCS) in MDD. This was a...

www.nature.com

screened 671 patients to get 20 suckers volunteers. 30% attrition rate out of those 20. total of 6 sham and 8 "active" patients.


all patients benefitted. the point they are making is that the treatment patients may have benefitted more. all 8 of them.

and in secondary measures, there were no real statistically significant differences in between the 2 groups.




in effect, a study to justify giving a patient a TENS unit.

If you told me my psych issues were in my back, I’d be pissed.